房新强：理学博士，课题组长，讲席教授

   联系方式：xqfang@ahnu.edu.cn

   办公室：花津校区礼勤楼719

   实验室：花津校区礼勤楼1109-1110

   课题组主页(临时)：http://www.fjirsm.ac.cn/fangxinqiang/

招生信息：每年招收博士、硕士多名

招生方向：有机化学、药物化学

欢迎热爱科研的青年才俊(高层次人才、博士后、博士、硕士、本科生)加入我们课题组！

个人简介：研究领域为不对称催化相关的合成化学，尤其是多位点羰基分子参与的催化转化及其在天然产物和药物分子合成中的应用，并注重与材料化学和化学生物学的结合。至今已在J. Am. Chem. Soc. (10篇)、 Angew. Chem. Int. Ed. (5篇)、 Nat. Commun. (1篇)、ACS Catal. (5篇)等杂志上发表论文80多篇，受邀撰写英文专著一章，授权专利四项，主持国家和省部级项目20余项。2005年硕士毕业于中国科学技术大学(导师：刘有成院士、吴云东院士),2009年博士毕业于中科院上海有机化学研究所(导师：李超忠研究员、刘有成院士),之后在新加坡南洋理工大学、德州农工大学、康奈尔大学从事博士后研究，2013年9月以“海西院百人计划”高层次人才引进到中国科学院福建物质结构研究所工作，任研究员，课题组长。2026年受聘为365英国上市网站官网讲席教授,课题组长。入选中组部海外高层次人才计划、中科院百人计划、福建省百人计划、福建省级高层次人才(A类)，获得Thieme Chemistry Journals Award、是中国化学会高级会员，担任《中国有机化学》青年编委和Nature出版社旗下Discover Chemistry编委。

代表性文章：

21. Ruthenium-Catalyzed Diversified Kinetic Resolutions of Diaryl-Substituted Cyclobutenones via Asymmetric Transfer Hydrogenation. Shouang Lan,+ Yingkun Luo,+ Chunyun Jiang, Chao Xu, Lili Zhao, Xiang Lei, Jieyang Dong, Jinggong Liu, Shuang Yang, Qi Zhang,* and Xinqiang Fang,* Angew. Chem. Int. Ed. 2025, 64, e202512543.

20. Copper-Catalyzed Asymmetric Nucleophilic Opening of 1,1,2,2-Tetrasubstituted Donor-Acceptor Cyclopropanes for the Synthesis of α-Tertiary Amines. Shouang Lan,+  Qinqin Cui,+  Defu Luo, Siyu Shi, Chengyang He, Shengyu Huang, Chao Xu, Lili Zhao, Jinggong Liu,* Cheng-Zhi Gu,* Shuang Yang, Xinqiang Fang,* J. Am. Chem. Soc. 2025, 147, 1172−1185.

19. Catalytic Asymmetric Transfer Hydrogenation of β,γ-Unsaturated α-Diketones. Zhifei Zhao,+ Wennan Dong,+ Jinggong Liu, Shuang Yang, Andrej Emanuel Cotman, Qi Zhang,* Xinqiang Fang,* J. Am. Chem. Soc. 2024, 146, 33543−33560.

18. Regio- and Stereoselective Transfer Hydrogenation of Aryloxy Group-Substituted Unsymmetrical 1,2-Diketones: Synthetic Applications and Mechanistic Studies. Wenjun Liu, Caiyi Ren, Liyuan Zhou, Haotian Luo, Xiangjian Meng, Peng Luo, Yingkun Luo, Wennan Dong, Shouang Lan, Jinggong Liu, Shuang Yang, Qi Zhang,* Xinqiang Fang,* J. Am. Chem. Soc. 2024, 146, 20092–20106.

17. Catalytic Asymmetric Transfer Hydrogenation of Acylboronates: BMIDA as the Privileged Directing Group. Xiangjian Meng,+  Shouang Lan,+  Ting Chen, Haotian Luo, Lixuan Zhu, Nanchu Chen, Jinggong Liu, Shuang Yang, Andrej Emanuel Cotman, Qi Zhang,* Xinqiang Fang,* J. Am. Chem. Soc. 2024, 146, 20357–20369.

16. Asymmetric Transfer Hydrogenation of Cyclobutenediones. Shouang Lan,+ Huangjiang Huang,+ Wenjun Liu, Chao Xu, Xiang Lei, Wennan Dong, Jinggong Liu, Shuang Yang, Andrej Emanuel Cotman, Qi Zhang,* and Xinqiang Fang,* J. Am. Chem. Soc. 2024, 146, 4942−4957.

15. Copper-catalyzed Asymmetric Yne-allylic Substitution Using Electron-rich Arenes. Defu Luo,+  Shengtong Niu,+ Fan Gong, Chao Xu, Shouang Lan, Jinggong Liu,* Shuang Yang, Xinqiang Fang,* ACS Catal. 2024, 14, 2746–2757.

14. Ruthenium-Catalyzed Formal Asymmetric Reductive Isomerization of α-Hydroxyenones. Wennan Dong, Caiyi Ren, Lixuan Zhu, Peng Luo, Zhifei Zhao, Shouang Lan, Jinggong Liu, Shuang Yang, Qi Zhang,* Xinqiang Fang,* ACS Catal. 2024, 14, 18753−18764.

13. Copper-catalyzed Umpolung Reactivity of Propargylic Carbonates in the Presence of Diboronates: One Stone Four Birds. Wennan Dong, Zhifei Zhao, Chengzhi Gu,* Jinggong Liu, Shuang Yang, Xinqiang Fang,* J. Am. Chem. Soc. 2023, 145, 27539−27554. (封面文章)

12. Copper-Catalyzed Rearrangement of Cyclic Ethynylethylene Carbonates: Synthetic Applications and Mechanistic Studies. Chao Xu,+ Hao Zhang,+ Shouang Lan, Jinggong Liu, Shuang Yang, Qi Zhang,* and Xinqiang Fang,* Angew. Chem. Int. Ed. 2023, 62, e202219064.

11. Dynamic Kinetic Resolution of β-Substituted α-Diketones via Asymmetric Transfer Hydrogenation. Ting Chen,+ Wenjun Liu,+ Wei Gu, Shengtong Niu, Shouang Lan, Zhifei Zhao, Fan Gong, Jinggong Liu, Shuang Yang, Andrej Emanuel Cotman, Jinshuai Song,* Xinqiang Fang,* J. Am. Chem. Soc. 2023, 145, 585−599.

10. Asymmetric Semipinacol Rearrangement Enabled by Copper-Catalyzed Propargylic Alkylation. Fan Gong,+  Xiangjian Meng,+ Shouang Lan, Jinggong Liu, Shuang Yang, Xinqiang Fang,* ACS Catal. 2022, 12, 12036−12044.

9. Copper-Catalyzed Yne-Allylic Substitutions Using Stabilized Nucleophiles. Shengtong Niu, Yingkun Luo, Chao Xu, Jinggong Liu, Shuang Yang, Xinqiang Fang,* ACS Catal. 2022, 12, 6840–6850.

8. Access to Enantioenriched Compounds Bearing Challenging Tetrasubstituted Stereocenters via Kinetic Resolution of Auxiliary Adjacent Alcohols. Shengtong Niu,+ Hao Zhang,+ Weici Xu,* Prasanta Ray Bagdi, Guoxiang Zhang, Jinggong Liu, Shuang Yang, and Xinqiang Fang,* Nat. Commun. 2021, 12: 3735.

7. Organocatalyzed Kinetic Resolution of a-Functionalized Ketones: the Malonate Unit Leads the Way. Jian Liu,+ Laxmaiah Vasamsetty,+ Muhammad Anwar,+ Shuang Yang,* Weici Xu,  Jinggong Liu, Sakkani Nagaraju, and Xinqiang Fang,* ACS Catal. 2020, 10, 2882−2893.

6. A Genetically Encoded Allysine for the Synthesis of Proteins with Site-Specific Lysine Dimethylation. Zhipeng A. Wang, Yu Zeng, Yadagiri Kurra, Xin Wang, Jeffery M. Tharp, Erol C. Vatansever, Willie W. Hsu, Susie Dai, Xinqiang Fang,* and Wenshe R. Liu,* Angew. Chem., Int. Ed. 2017, 56, 212−216.  

5. Dynamic Kinetic Resolution Enabled by Intramolecular Benzoin Reaction: Synthetic Applications and Mechanistic Insights. Guoxiang Zhang, Shuang Yang, Xiaoyan Zhang, Qiqiao Lin, Deb K. Das, Jian Liu, and Xinqiang Fang,* J. Am. Chem. Soc. 2016, 138, 7932−7938.

Before Independence:

4. Fang, X.+ ; Fu, Y.+ ; Long, M. C.; Haegele, J. A.; Ge, E. J.; Parvez, S.; Aye, Y.* Temporally Controlled Targeting of 4-Hydroxynonenal to Specific Proteins in Living Cells. J. Am. Chem. Soc. 2013, 135, 14496−14499. (+ contributed equally).

3. Fang, X.; Chen, X.; Lv, H.; Chi, Y. R.* Enantioselective Stetter Reactions of Enals and Modified Chalcones Catalyzed by N-Heterocyclic Carbene. Angew. Chem. Int. Ed. 2011, 50, 11782−11785.

2. Fang, X.; Jiang, K.; Xing, C.; Hao, L.; Chi, Y. R.* A Highly Regio- and Stereoselective Cascade Annulation of Enals and Benzodi(enone)s Catalyzed by N-Heterocyclic Carbenes. Angew. Chem. Int. Ed. 2011, 50, 1910−1913.

1. Fang, X.; Liu, K.; Li, C.* Efficient Regio- and Stereoselective Formation of Azocan-2-ones via 8-Endo Cyclization of α-Carbamoyl Radicals. J. Am. Chem. Soc. 2010, 132, 2274−2283.

授权专利：

1. 房新强, 孙德谦, 杨爽, “苯并硼唑类化合物的制备方法”，中国发明专利，2022年，专利号： CN113121578B

2. 房新强, 刘剑, 杨爽, “一种手性a-氟代酮化合物的制备方法”，中国发明专利，2022年，专利号： CN112279765B

3. 房新强, 刘剑, 杨爽, “一种手性a-氘代酮的制备方法”，中国发明专利，2022年，专利号：CN112299996B

4. 房新强, 张浩, 杨爽, “一种联烯醇类化合物的制备方法”，中国发明专利，2024年，专利号：CN116102403B